CANNABINOID THERAPEUTICS

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Cannabinoids

Cannabinoids are compounds found in cannabis that are located within the trichomes of the plant’s flower. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol, commonly known as THC, which is the primary psychoactive compound in cannabis that interacts with our CB1 Receptor. Cannabidiol, or CBD, is another major compound of the plant that interacts with our CB2 Receptor.

Evidence suggests that there are at least 144 different cannabinoids isolated from cannabis as well as several hundreds of secondary compounds which include terpenes and flavonoids, all of which exhibit varied effects.

CBD formula

Cannabidiol: CBD

THC Formula

Tetrahydrocannabinol: THC

CBC Formula

Cannabichromen: CBC

CBN Formula

Cannabinol: CBN

CBG Formula

Cannabigerol: CBG

CBD formula

Cannabidiol: CBD –
“The Medicinal Cannabinoid”

CBD is a non-psychoactive cannabinoid that’s one of the most abundant compounds in cannabis. The cannabinoid which is psychoactive is THC. Researchers are fascinated by CBD because it seems to offer many health benefits without the psychoactive drawbacks of THC. A few of the better-studied conditions CBD seems to be beneficial for include schizophrenia, epilepsy, and certain forms of cancer. There’s also great hope that CBD could help with chronic pain conditions like fibromyalgia and mental conditions like anxiety and depression.

 

Since the passage of the 2018 Farm Bill, the marketplace for this non-psychoactive cannabinoid has exploded. Some researchers estimate CBD oil sales could go over the $20 billion mark within a few years.

THC Formula

Tetrahydrocannabinol: THC –
“The Bad Boy Cannabinoid”

Yes, THC is the cannabinoid that makes you “high.” According to federal law, THC, or marijuana, is listed as a schedule 1 narcotic under the Controlled Substances Act and is illegal to poses, sell, or consume. While THC is federally illegal, 16 U.S. States have legalized THC for adult-use while 35 states have legalized for medicinal-use and 16 states have decriminalized cannabis.

There’s a great deal of evidence that suggests this cannabinoid could help when used in the proper proportions. It’s well known that THC has a powerful analgesic effect, which could seriously help many people suffering from pain. Recent research has also shown that THC could reduce eye pressure in glaucoma patients and help chemo patients with poor appetite. Interestingly, CBD oil was found to have the exact opposite effect on glaucoma patients, which proves that different cannabinoids need to be used for different conditions.

CBC Formula

Cannabichromen: CBC –
“The Forgotten One”

Let’s move on to a lesser-known cannabinoid: cannabichromene (CBC). Although less studied than CBD and THC, CBC does show great promise as a therapy for numerous conditions, especially chronic pain.
Many of the studies on CBC’s effect on the human body looked into its ability to block the perception of pain. For instance, the Second University of Naples found that CBC in combination with CBD decreased pain signals in a group of mice. Another study looking into this issue discovered CBC combined with THC had a powerful anti-inflammatory effect on mice.

Although most of the press on CBC is related to chronic pain, many doctors believe that’s only the beginning of CBC’s healing potential. Other studies looking into CBC have suggested it could repair brain damage, get rid of acne, and even improve mental health.

CBN Formula

Cannabinol: CBN –
“The Phoenix”

Cannabinol (CBN) is an interesting cannabinoid because it’s only created after THC degenerates. This means you’ll only find high quantities of CBN on plants that have been exposed to oxygen for longer periods of time. However, recent findings have sparked a new discussion about this mysterious cannabinoid. Researchers are still trying to figure out how CBN works, but it seems to attach to the brain’s CB1 receptor. Today, scientists are most interested in CBN for its potential to treat sleeping disorders like insomnia. Current research suggests CBN works as a powerful sedative. A study by Steep Hill Labs claims that 2.5-5mg of CBN has the same effect as a 5-10mg dose of diazepam. This research has sparked interest in CBN, which was largely ignored by the cannabis industry due to the fact that it was mostly found in older cannabis plants.
CBG Formula

Cannabigerol: CBG –
“The Mother Cannabinoid”

Unlike CBN, which appears after THC disintegrates, the cannabinoid cannabigerol (CBG) is the forerunner of both THC and CBD. It is known as the “Mother of All Cannabinoids” because it is made by the plant first and then it facilitates the making of the other cannabinoids. Despite this interesting factoid, CBG is usually ignored because it only makes up about 1 percent of total cannabinoids. A growing community of cannabis growers are working on breeding plants that will yield higher quantities of CBG. Many in the medical marijuana industry believe this compound could help with a wide variety of issues ranging from digestive disorders to eye disease. One Polish study showed promising results for CBG’s ability to reduce eye pressure in patients with glaucoma. A few other conditions that CBG seems to help with include colorectal cancer, irritable bowel disease, and bladder issues like interstitial cystitis.

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